SYNTHESIS , TRITIATION AND BIOLOGICAL STUDIES WITH [ 2 - 0 - METHYL - TYROSINE , 7 - ( 3 , 4 - DEHYDROPROLINEjDEAMINO - I - CARBA - OXYTOCIN
نویسنده
چکیده
Introduction Recognition of biological properties of Carbetocin [2-0-rnethy~ tyrosine]deamino-l-carba-oxytocin (I) (1-3) resulted in the introduction of this compound into veterinary practice as a drug with selective uterotonic and milk-ejecting action (Depotocin-Spofa and Decomoton-Nordvacc) In order to elucidate further properties j metabolism and distribution of Carbetocin we decided to prepare its radioactively labelled form. Van Nispen at al. (4) described unsuccessful attempts of tritiation of dehydroproline containing oxytocin analogues. We tried to apply this principle of labelling in the case of mono-carba analogue in the hope that the sulfide containing compound may behave differently then disulfide-containing one.
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